DanceTherParkinsonV1, Main, Exploration, bibRecord, 000103

Effects of a formal exercise program on Parkinson’s disease: A pilot study using a delayed start design

Identifieur interne : 000103 ( Main/Exploration ); précédent : 000102; suivant : 000104

Effects of a formal exercise program on Parkinson’s disease: A pilot study using a delayed start design

Auteurs : A. Park [États-Unis] ; D. Zid [États-Unis] ; J. Russell [États-Unis] ; A. Malone [États-Unis] ; A. Rendon [États-Unis] ; A. Wehr [États-Unis] ; X. Li [États-Unis]

Source :

Parkinsonism & related disorders [ 1353-8020 ] ; 2013.

RBID : PMC:4030674

Abstract

Introduction

Parkinson’s Disease (PD) is a progressive neurodegenerative disease. Increasing evidence shows that physical exercise is beneficial for motor and non-motor symptoms of PD, and animal models suggest that it may help slow progression of disease.

Methods

Using a randomized delayed-start design, 31 patients were randomized to an early start group (ESG) or a delayed start group (DSG) exercise program. The ESG underwent a rigorous formal group exercise program for 1 h, three days/week, for 48 weeks (November 2011–October 2012). The DSG participated in this identical exercise program from weeks 24–48. Outcome measures included the Unified Parkinson’s Disease Rating Scale (UPDRS), Walking Test (get-up-and-go), Tinetti Mobility Test, PDQ-39 Questionnaire, and the Beck Depression Inventory.

Results

There was minimal attrition in this study, with only one patient dropping out. Results did not show improvement in total UPDRS scores with early exercise. At week 48, the mean change from baseline total UPDRS score was 6.33 in the ESG versus 5.13 in the DSG (p = 0.58). However, patients randomized to the ESG scored significantly better on the Beck Depression Inventory, with a mean improvement of 1.07 points relative to those in the DSG (p = 0.04).

Conclusions

The findings demonstrate that long-term, group exercise programs are feasible in the Parkinson’s disease population, with excellent adherence and minimal drop out. While the outcome measures used in our study did not provide strong evidence that exercise has a neuroprotective effect on motor function, earlier participation in a group exercise program had a significant effect on symptoms of depression.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030674

DOI: 10.1016/j.parkreldis.2013.10.003
PubMed: 24209458
PubMed Central: 4030674

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of a formal exercise program on Parkinson’s disease: A pilot study using a delayed start design</title>
<author><name sortKey="Park, A" sort="Park, A" uniqKey="Park A" first="A." last="Park">A. Park</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, The Ohio State University, Columbus, OH 43210</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zid, D" sort="Zid, D" uniqKey="Zid D" first="D." last="Zid">D. Zid</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Columbus Health Works, Columbus, OH 43212, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Columbus Health Works, Columbus, OH 43212</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Russell, J" sort="Russell, J" uniqKey="Russell J" first="J." last="Russell">J. Russell</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Columbus Health Works, Columbus, OH 43212, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Columbus Health Works, Columbus, OH 43212</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malone, A" sort="Malone, A" uniqKey="Malone A" first="A." last="Malone">A. Malone</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, The Ohio State University, Columbus, OH 43210</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rendon, A" sort="Rendon, A" uniqKey="Rendon A" first="A." last="Rendon">A. Rendon</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, The Ohio State University, Columbus, OH 43210</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wehr, A" sort="Wehr, A" uniqKey="Wehr A" first="A." last="Wehr">A. Wehr</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Biostatistics, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Biostatistics, The Ohio State University, Columbus, OH 43210</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, X" sort="Li, X" uniqKey="Li X" first="X." last="Li">X. Li</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Biostatistics, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Biostatistics, The Ohio State University, Columbus, OH 43210</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24209458</idno>
<idno type="pmc">4030674</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030674</idno>
<idno type="RBID">PMC:4030674</idno>
<idno type="doi">10.1016/j.parkreldis.2013.10.003</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000269</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000269</idno>
<idno type="wicri:Area/Pmc/Curation">000157</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000157</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000084</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000084</idno>
<idno type="wicri:Area/Ncbi/Merge">000148</idno>
<idno type="wicri:Area/Ncbi/Curation">000148</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000148</idno>
<idno type="wicri:doubleKey">1353-8020:2013:Park A:effects:of:a</idno>
<idno type="wicri:Area/Main/Merge">000103</idno>
<idno type="wicri:Area/Main/Curation">000103</idno>
<idno type="wicri:Area/Main/Exploration">000103</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of a formal exercise program on Parkinson’s disease: A pilot study using a delayed start design</title>
<author><name sortKey="Park, A" sort="Park, A" uniqKey="Park A" first="A." last="Park">A. Park</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, The Ohio State University, Columbus, OH 43210</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zid, D" sort="Zid, D" uniqKey="Zid D" first="D." last="Zid">D. Zid</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Columbus Health Works, Columbus, OH 43212, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Columbus Health Works, Columbus, OH 43212</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Russell, J" sort="Russell, J" uniqKey="Russell J" first="J." last="Russell">J. Russell</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Columbus Health Works, Columbus, OH 43212, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Columbus Health Works, Columbus, OH 43212</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Malone, A" sort="Malone, A" uniqKey="Malone A" first="A." last="Malone">A. Malone</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, The Ohio State University, Columbus, OH 43210</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rendon, A" sort="Rendon, A" uniqKey="Rendon A" first="A." last="Rendon">A. Rendon</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, The Ohio State University, Columbus, OH 43210</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wehr, A" sort="Wehr, A" uniqKey="Wehr A" first="A." last="Wehr">A. Wehr</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Biostatistics, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Biostatistics, The Ohio State University, Columbus, OH 43210</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, X" sort="Li, X" uniqKey="Li X" first="X." last="Li">X. Li</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Center for Biostatistics, The Ohio State University, Columbus, OH 43210, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Biostatistics, The Ohio State University, Columbus, OH 43210</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Parkinsonism & related disorders</title>
<idno type="ISSN">1353-8020</idno>
<idno type="eISSN">1873-5126</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Introduction</title>
<p id="P1">Parkinson’s Disease (PD) is a progressive neurodegenerative disease. Increasing evidence shows that physical exercise is beneficial for motor and non-motor symptoms of PD, and animal models suggest that it may help slow progression of disease.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Using a randomized delayed-start design, 31 patients were randomized to an early start group (ESG) or a delayed start group (DSG) exercise program. The ESG underwent a rigorous formal group exercise program for 1 h, three days/week, for 48 weeks (November 2011–October 2012). The DSG participated in this identical exercise program from weeks 24–48. Outcome measures included the Unified Parkinson’s Disease Rating Scale (UPDRS), Walking Test (get-up-and-go), Tinetti Mobility Test, PDQ-39 Questionnaire, and the Beck Depression Inventory.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">There was minimal attrition in this study, with only one patient dropping out. Results did not show improvement in total UPDRS scores with early exercise. At week 48, the mean change from baseline total UPDRS score was 6.33 in the ESG versus 5.13 in the DSG (<italic>p</italic>
 = 0.58). However, patients randomized to the ESG scored significantly better on the Beck Depression Inventory, with a mean improvement of 1.07 points relative to those in the DSG (<italic>p</italic>
 = 0.04).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">The findings demonstrate that long-term, group exercise programs are feasible in the Parkinson’s disease population, with excellent adherence and minimal drop out. While the outcome measures used in our study did not provide strong evidence that exercise has a neuroprotective effect on motor function, earlier participation in a group exercise program had a significant effect on symptoms of depression.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Ohio</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Ohio"><name sortKey="Park, A" sort="Park, A" uniqKey="Park A" first="A." last="Park">A. Park</name>
</region>
<name sortKey="Li, X" sort="Li, X" uniqKey="Li X" first="X." last="Li">X. Li</name>
<name sortKey="Malone, A" sort="Malone, A" uniqKey="Malone A" first="A." last="Malone">A. Malone</name>
<name sortKey="Rendon, A" sort="Rendon, A" uniqKey="Rendon A" first="A." last="Rendon">A. Rendon</name>
<name sortKey="Russell, J" sort="Russell, J" uniqKey="Russell J" first="J." last="Russell">J. Russell</name>
<name sortKey="Wehr, A" sort="Wehr, A" uniqKey="Wehr A" first="A." last="Wehr">A. Wehr</name>
<name sortKey="Zid, D" sort="Zid, D" uniqKey="Zid D" first="D." last="Zid">D. Zid</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/DanceTherParkinsonV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000103 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000103 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Psychologie
   |area=    DanceTherParkinsonV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4030674
   |texte=   Effects of a formal exercise program on Parkinson’s disease: A pilot study using a delayed start design
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24209458" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a DanceTherParkinsonV1

This area was generated with Dilib version V0.6.35.
Data generation: Sun Aug 9 17:42:30 2020. Site generation: Mon Feb 12 22:53:51 2024

Danse-thérapie et Parkinson

Effects of a formal exercise program on Parkinson’s disease: A pilot study using a delayed start design

Effects of a formal exercise program on Parkinson’s disease: A pilot study using a delayed start design

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Danse-thérapie et Parkinson
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.